Recombinant Human 5′-3′ exoribonuclease 2 (XRN2), Truncated

Uniprot Id

Q9H0D6

Target Species

Human

Target Name

XRN2

Target Full Name

5'-3' exoribonuclease 2

Target Function

Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites.

Target Subcellular Location

Nucleus, nucleolus.

Target Protein Families

5'-3' exonuclease family, XRN2/RAT1 subfamily

Target Tissue Specificity

Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.

Target Synonyms

XRN2; 5'-3' exoribonuclease 2; EC 3.1.13.-; DHM1-like protein; DHP protein

Target Background

This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms.