Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), Truncated

Uniprot Id

O75173

Target Species

Human

Target Name

ADAMTS4

Target Full Name

A disintegrin and metalloproteinase with thrombospondin motifs 4

Target Function

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Tissue Specificity

Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2: Detected in osteoarthritic synovium.

Target Research Area

Cancer

Target Synonyms

A disintegrin and metalloproteinase with thrombospondin motifs 4; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 4; A disintegrin like and metalloprotease with thrombospondin type 1 motif 4; ADAM metallopeptidase with thrombospondin type 1 motif 4; ADAM TS 4; ADAM TS4; ADAM-TS 4; ADAM-TS4; ADAMTS 2; ADAMTS 4; ADAMTS-4; ADAMTS2; ADAMTS4; ADAMTS4 protein; ADMP 1; ADMP-1; ADMP1; Aggrecanase 1; Aggrecanase-1; Aggrecanase1; ATS4_HUMAN; KIAA0688

Target Background

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.