Recombinant Human A/G-specific adenine DNA glycosylase (MUTYH)

Uniprot Id

Q9UIF7

Target Species

Human

Target Name

MUTYH

Target Full Name

Adenine DNA glycosylase

Target Function

Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.

Target Involvement

Familial adenomatous polyposis 2 (FAP2); Gastric cancer (GASC)

Target Subcellular Location

Nucleus. Mitochondrion.

Target Protein Families

Nth/MutY family

Target Synonyms

A/G specific adenine DNA glycosylase; A/G-specific adenine DNA glycosylase; Adenine DNA glycosylase ; CYP2C; hMYH; MGC4416; MutY (E. coli) homolog ; MutY homolog (E. coli); MutY homolog; MutY, E. coli, homolog of; Mutyh; MUTYH_HUMAN; MYH; rMYH

Target Background

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7, 8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.