Recombinant Human Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)

Uniprot Id

Q9NR19

Target Species

Human

Target Name

ACSS2

Target Full Name

Acetyl-coenzyme A synthetase, cytoplasmic

Target Function

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity.

Target Subcellular Location

Cytoplasm, cytosol.

Target Protein Families

ATP-dependent AMP-binding enzyme family

Target Synonyms

ACAS2; AceCS; Acetate CoA ligase; Acetate thiokinase; Acetate--CoA ligase; Acetyl CoA synthetase; Acetyl Coenzyme A synthetase 2 (ADP forming); Acetyl coenzyme A synthetase cytoplasmic; Acetyl-CoA synthetase; Acetyl-coenzyme A synthetase; ACS; ACSA; ACSA_HUMAN; ACSS2; Acyl activating enzyme; Acyl CoA synthetase short chain family member 2; Acyl-activating enzyme; Acyl-CoA synthetase short-chain family member 2; Cytoplasmic acetyl coenzyme A synthetase; cytoplasmic; MYH7B

Target Background

This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.