Recombinant Human Acetylcholinesterase (ACHE)

Cat.No	ACP00390	Target Name	ache
Target Synonyms	AChE	Form	Liquid or Lyophilized powder
Expression System	Mammalian cell	Expression Range	32-614aa
Mol Weight	66.0 kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 95% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00390

Target Name

ache

Target Synonyms

AChE

Form

Liquid or Lyophilized powder

Expression System

Mammalian cell

Expression Range

32-614aa

Mol Weight

66.0 kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 95% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P22303

Background Information

Uniprot Id

P22303
Target Species

Human
Target Name

ACHE
Target Full Name

Acetylcholinesterase
Target Function

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Target Subcellular Location

Cell junction, synapse. Secreted. Cell membrane; Peripheral membrane protein.; [Isoform T]: Nucleus. Note=Only observed in apoptotic nuclei.; [Isoform H]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Target Protein Families

Type-B carboxylesterase/lipase family
Target Tissue Specificity

Isoform H is highly expressed in erythrocytes.
Target Research Area

Others
Target Synonyms

ACEE; ACES_HUMAN; Acetylcholinesterase; AChE; Apoptosis related acetylcholinesterase; ARACHE; N ACHE; N-ACHE; YT; YT blood group
Target Background

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo, and thus, may be of aid in understanding the effects of transfusion

Recombinant Human Acetylcholinesterase (ACHE)

Specifications

Immunogen Information

Inquire Recombinant Human Acetylcholinesterase (ACHE) Now

Related Products