Recombinant Human Acetylserotonin O-methyltransferase (ASMT)

Uniprot Id

P46597

Target Species

Human

Target Name

ASMT

Target Full Name

Acetylserotonin O-methyltransferase

Target Function

Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.

Target Protein Families

Class I-like SAM-binding methyltransferase superfamily, Cation-independent O-methyltransferase family

Target Tissue Specificity

Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level, and not at the protein level.

Target Research Area

Cell Biology

Target Synonyms

acetylserotonin methyltransferase (Y chromosome); acetylserotonin N-methyltransferase; Acetylserotonin O-methyltransferase; ASMT; ASMTY; HIOM_HUMAN; HIOMT; HIOMTY; Hydroxyindole O-methyltransferase; OTTHUMP00000022834; OTTHUMP00000022835; OTTHUMP00000022836

Target Background

This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene.