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The expression region of this recombinant Human ACTA1 covers amino acids 3-377. This ACTA1 protein is expected to have a theoretical molecular weight of 45.8 kDa. Expression of this ACTA1 protein is conducted in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of ACTA1, making it easier to detect and purify the ACTA1 recombinant protein in the later stages of expression and purification.Actin, alpha skeletal muscle (ACTA1) is a widely expressed protein in muscle tissue, primarily involved in the study of muscle biology. In this field, ACTA1 plays a crucial role as it constitutes an essential component of the cell skeleton in muscle cells. Researchers focus on understanding the function of ACTA1 in muscle contraction and movement processes, as well as its role in maintaining muscle structure and stability. One of the most significant research directions is exploring the relationship between ACTA1 and muscle diseases, such as muscular dystrophy. Scientists also investigate the mechanisms of ACTA1 involvement in muscle regeneration and repair, which holds important implications for treating muscle injuries and diseases.
The expression region of this recombinant Human ACTA1 covers amino acids 3-377. This ACTA1 protein is expected to have a theoretical molecular weight of 45.8 kDa. Expression of this ACTA1 protein is conducted in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of ACTA1, making it easier to detect and purify the ACTA1 recombinant protein in the later stages of expression and purification.Actin, alpha skeletal muscle (ACTA1) is a widely expressed protein in muscle tissue, primarily involved in the study of muscle biology. In this field, ACTA1 plays a crucial role as it constitutes an essential component of the cell skeleton in muscle cells. Researchers focus on understanding the function of ACTA1 in muscle contraction and movement processes, as well as its role in maintaining muscle structure and stability. One of the most significant research directions is exploring the relationship between ACTA1 and muscle diseases, such as muscular dystrophy. Scientists also investigate the mechanisms of ACTA1 involvement in muscle regeneration and repair, which holds important implications for treating muscle injuries and diseases.
| Cat.No | ACP04209 | Target Name | ACTA1 |
|---|---|---|---|
| Target Synonyms | a actin; ACTA; ACTA1; ACTA2; ACTC; ACTC1; Actin; ACTS_HUMAN; ACTSA; Alpha 2 actin; alpha skeletal muscle; Alpha-actin-1; Cardiac muscle alpha actin 1; Skeletal muscle alpha actin 1 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 3-377aa |
| Mol Weight | 45.8kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P68133 |
|---|
Uniprot Id
P68133
Target Species
Human
Target Name
ACTA1
Target Full Name
Actin, alpha skeletal muscle
Target Function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Target Involvement
Nemaline myopathy 3 (NEM3); Myopathy, actin, congenital, with excess of thin myofilaments (MPCETM); Myopathy, congenital, with fiber-type disproportion (CFTD); Myopathy, scapulohumeroperoneal (SHPM)
Target Subcellular Location
Cytoplasm, cytoskeleton.
Target Protein Families
Actin family
Target Research Area
Signal Transduction
Target Synonyms
a actin; ACTA; ACTA1; ACTA2; ACTC; ACTC1; Actin; ACTS_HUMAN; ACTSA; Alpha 2 actin; alpha skeletal muscle; Alpha-actin-1; Cardiac muscle alpha actin 1; Skeletal muscle alpha actin 1
Target Background
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause a variety of myopathies, including nemaline myopathy, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects with manifestations such as hypotonia.
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