Recombinant Human Actin-related protein 3B (ACTR3B)

Uniprot Id

Q9P1U1

Target Species

Human

Target Name

ACTR3B

Target Full Name

Actin-related protein 3B

Target Function

Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.

Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection.

Target Protein Families

Actin family, ARP3 subfamily

Target Tissue Specificity

Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adeno

Target Synonyms

ACTR3B; ARP11; ARP4Actin-related protein 3B; ARP3-beta; Actin-like protein 3B; Actin-related protein ARP4

Target Background

This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms.