Recombinant Human Activating signal cointegrator 1 complex subunit 1 (ASCC1)

Uniprot Id

Q8N9N2

Target Species

Human

Target Name

ASCC1

Target Full Name

Activating signal cointegrator 1 complex subunit 1

Target Function

Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.

Target Involvement

Barrett esophagus (BE); Spinal muscular atrophy with congenital bone fractures 2 (SMABF2)

Target Subcellular Location

Nucleus. Nucleus speckle.

Target Tissue Specificity

Ubiquitous.

Target Research Area

Signal Transduction

Target Synonyms

Activating signal cointegrator 1 complex subunit 1; ASC-1 complex subunit p50; ASC1 complex subunit p50 ; ASC1p50; ASCC1; ASCC1_HUMAN; CGI 18; RP11-150D20.4; Trip4 complex subunit p50

Target Background

This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.