Recombinant Human Adenylate cyclase type 7 (ADCY7), Truncated

Uniprot Id

P51828

Target Species

Human

Target Name

ADCY7

Target Full Name

Adenylate cyclase type 7

Target Function

Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors. Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex. Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Adenylyl cyclase class-4/guanylyl cyclase family

Target Synonyms

ADCY7; KIAA0037Adenylate cyclase type 7; EC 4.6.1.1; ATP pyrophosphate-lyase 7; Adenylate cyclase type VII; Adenylyl cyclase 7