Recombinant Human ADP-ribose pyrophosphatase, mitochondrial (NUDT9)

Uniprot Id

Q9BW91

Target Species

Human

Target Name

NUDT9

Target Full Name

ADP-ribose pyrophosphatase, mitochondrial

Target Function

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.

Target Subcellular Location

[Isoform 1]: Mitochondrion.

Target Protein Families

Nudix hydrolase family, NudF subfamily

Target Tissue Specificity

Ubiquitously expressed but isoform 1 is the most predominant isoform.

Target Synonyms

Adenosine diphosphoribose pyrophosphatase; ADP ribose diphosphatase; ADP ribose phosphohydrolase; ADP ribose pyrophosphatase, mitochondrial precursor; ADP ribose pyrosphosphatase NUDT9; ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ADP-ribose pyrophosphatase, mitochondrial; ADPR PPase; ADPR-PPase; EC 3.6.1.13; Nucleoside diphosphate linked moiety X motif 9; Nucleoside diphosphate linked moiety X type motif 9; Nucleoside diphosphate-linked moiety X motif 9; Nudix (nucleoside diphosphate linked moiety X) type motif 9; Nudix hydrolase 9; Nudix motif 9; NUDT10; NUDT9; NUDT9_HUMAN

Target Background

The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.