Recombinant Human Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)

Cat.No	ACP21125	Target Name	AKR7A2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-359	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP21125

Target Name

AKR7A2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-359

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O43488

Background Information

Uniprot Id

O43488
Target Species

Human
Target Name

AKR7A2
Target Full Name

Aflatoxin B1 aldehyde reductase member 2
Target Function

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Target Subcellular Location

Golgi apparatus. Cytoplasm.
Target Protein Families

Aldo/keto reductase family, Aldo/keto reductase 2 subfamily
Target Tissue Specificity

Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels
Target Synonyms

AFAR; AFAR1; AFB1 aldehyde reductase 1; AFB1 AR1; AFB1-AR 1; AFB1AR1; Aflatoxin aldehyde reductase; Aflatoxin B1 aldehyde reductase member 2; Aflatoxin beta1 aldehyde reductase; Aiar; AKR7; Akr7a2; Aldo keto reductase family 7; Aldo keto reductase family 7 member A2 aflatoxin aldehyde reductase; Aldo keto reductase family 7 member A2; Aldo keto reductase family 7; member A2 (aflatoxin aldehyde reductase); Aldoketoreductase 7; ARK72_HUMAN; SSA reductase; Succinic semialdehyde reductase
Target Background

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.

Recombinant Human Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)

Specifications

Immunogen Information

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