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Recombinant Human Alanine–tRNA ligase, mitochondrial (AARS2), Truncated

ACP17119

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Specifications

Cat.No	ACP17119	Target Name	AARS2
Target Synonyms	AARS2; AARSL; KIAA1270; Alanine--tRNA ligase; mitochondrial; EC 6.1.1.7; Alanyl-tRNA synthetase; AlaRS	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q5JTZ9

Background Information

Uniprot Id

Q5JTZ9
Target Species

Human
Target Name

AARS2
Target Full Name

Alanine--tRNA ligase, mitochondrial
Target Function

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Target Involvement

Combined oxidative phosphorylation deficiency 8 (COXPD8); Leukoencephalopathy, progressive, with ovarian failure (LKENP)
Target Subcellular Location

Mitochondrion.
Target Protein Families

Class-II aminoacyl-tRNA synthetase family
Target Synonyms

AARS2; AARSL; KIAA1270; Alanine--tRNA ligase; mitochondrial; EC 6.1.1.7; Alanyl-tRNA synthetase; AlaRS
Target Background

The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.

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Recombinant Human Alanine–tRNA ligase, mitochondrial (AARS2), Truncated

Specifications

Immunogen Information

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