Recombinant Human albumin (ALB)

Uniprot Id

P02768

Target Species

Human

Target Name

ALB

Target Full Name

Albumin

Target Function

Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin.

Target Involvement

Hyperthyroxinemia, familial dysalbuminemic (FDAH); Analbuminemia (ANALBA)

Target Subcellular Location

Secreted.

Target Protein Families

ALB/AFP/VDB family

Target Tissue Specificity

Plasma.

Target Synonyms

alb; ALBU_HUMAN; Albumin (32 AA); Albumin (AA 34); cell growth inhibiting protein 42; DKFZp779N1935; GIG20; GIG42; Growth inhibiting protein 20; growth-inhibiting protein 20; OTTHUMP00000220436; OTTHUMP00000220438; OTTHUMP00000220439; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619; PRO2675; Serum albumin; UNQ696/PRO1341

Target Background

This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as well as exogenous drugs. Additionally, this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine receptor.