Recombinant Human Aldehyde dehydrogenase family 1 member A3 (ALDH1A3)

Uniprot Id

P47895

Target Species

Human

Target Name

ALDH1A3

Target Full Name

Retinaldehyde dehydrogenase 3

Target Function

NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde. Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region.

Target Involvement

Microphthalmia, isolated, 8 (MCOP8)

Target Subcellular Location

Cytoplasm.

Target Protein Families

Aldehyde dehydrogenase family

Target Tissue Specificity

Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.

Target Research Area

Others

Target Synonyms

Acetaldehyde dehydrogenase 6; AL1A3_HUMAN; Aldehyde dehydrogenase 1A3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; Aldh1a3; ALDH1A6; ALDH6; RALDH 3; Retinaldehyde dehydrogenase 3; V1

Target Background

This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants.