Recombinant Human Aldehyde dehydrogenase family 3 member A2 (ALDH3A2), Truncated

Uniprot Id

P51648

Target Species

Human

Target Name

ALDH3A2

Target Full Name

Aldehyde dehydrogenase family 3 member A2

Target Function

Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.

Target Involvement

Sjoegren-Larsson syndrome (SLS)

Target Subcellular Location

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Target Protein Families

Aldehyde dehydrogenase family

Target Tissue Specificity

Detected in liver (at protein level).

Target Synonyms

ALDH3A2; ALDH10; FALDH; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10; Fatty aldehyde dehydrogenase; Microsomal aldehyde dehydrogenase

Target Background

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.