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| Cat.No | ACP19783 | Target Name | AKR1B15 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-344 | Protein Length | Full Length of Isoform 2 |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | C9JRZ8 |
|---|
Uniprot Id
C9JRZ8
Target Species
Human
Target Name
AKR1B15
Target Full Name
Aldo-keto reductase family 1 member B15
Target Function
Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal. May play a physiological role in retinoid metabolism.; No oxidoreductase activity observed with the tested substrates.
Target Subcellular Location
[Isoform 1]: Mitochondrion.; [Isoform 2]: Cytoplasm, cytosol.
Target Protein Families
Aldo/keto reductase family
Target Tissue Specificity
Widely expressed. Expressed at highest levels in steroid-sensitive tissues, such as placenta, testis and adipose tissue.
Target Synonyms
AKR1B15Aldo-keto reductase family 1 member B15; EC 1.1.1.-; EC 1.1.1.300; EC 1.1.1.54; Estradiol 17-beta-dehydrogenase AKR1B15; Farnesol dehydrogenase; EC 1.1.1.216; Testosterone 17beta-dehydrogenase; EC 1.1.1.64
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