Recombinant Human Alpha- (1,3)-fucosyltransferase (FUT5), Truncated

Uniprot Id

Q11128

Target Species

Human

Target Name

FUT5

Target Full Name

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5

Target Function

Catalyzes preferentially the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl-beta-D-glucosamine (GlcNAc) of an N-acetyllactosamine unit (type 2 chain) of an oligosacccharide, or a glycoprotein- and a glycolipid-linked N-acetyllactosamine unit via an alpha (1,3) linkage and participates in the surface espression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens. Preferentially transfers fucose to the GlcNAc of an internal N-acetyllactosamine unit of a poly-N-acetyllactosamine chain acceptor substrate. Also catalyzes to a lesser extend the transfer of L-fucose to the GlcNAc of a type 1 (beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl) or H-type 1 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc) chain oligosacccharide via an alpha (1,4) linkage. Preferentially catalyzes sialylated type 2 oligosacccharide acceptors over neutral type 2 or H type 2 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc) oligosacccharide acceptors. Lactose-based structures are also acceptor substrates

Target Subcellular Location

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Target Protein Families

Glycosyltransferase 10 family

Target Tissue Specificity

Liver, colon and testis and trace amounts in T-cells and brain.

Target Synonyms

FUT5Alpha-(1,3)-fucosyltransferase 5; EC 2.4.1.65; Fucosyltransferase 5; Fucosyltransferase V; Fuc-TV; FucT-V; Galactoside 3-L-fucosyltransferase