Recombinant Human Alpha-1A adrenergic receptor (ADRA1A)

Cat.No	ACP02158	Target Name	ADRA1A
Target Synonyms	Alpha-1A adrenoreceptor;Alpha-1A adrenoceptor;Alpha-1C adrenergic receptor;Alpha-adrenergic receptor 1c	Form	Liquid or Lyophilized powder
Expression System	in vitro E.coli expression system	Expression Range	1-466aa
Mol Weight	53.0 kDa	Protein Length	Full length
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02158

Target Name

ADRA1A

Target Synonyms

Alpha-1A adrenoreceptor;Alpha-1A adrenoceptor;Alpha-1C adrenergic receptor;Alpha-adrenergic receptor 1c

Form

Liquid or Lyophilized powder

Expression System

in vitro E.coli expression system

Expression Range

1-466aa

Mol Weight

53.0 kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P35348

Background Information

Uniprot Id

P35348
Target Species

Human
Target Name

ADRA1A
Target Full Name

Alpha-1A adrenergic receptor
Target Function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Target Subcellular Location

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
Target Protein Families

G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA1A sub-subfamily
Target Tissue Specificity

Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with hi
Target Research Area

Neuroscience
Target Synonyms

ADRA1A; ADRA1C; Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c
Target Background

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.

Recombinant Human Alpha-1A adrenergic receptor (ADRA1A)

Specifications

Immunogen Information

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