Recombinant Human Alpha-hemoglobin-stabilizing protein (AHSP)

Uniprot Id

Q9NZD4

Target Species

Human

Target Name

AHSP

Target Full Name

Alpha-hemoglobin-stabilizing protein

Target Function

Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.

Target Subcellular Location

Cytoplasm.

Target Protein Families

AHSP family

Target Tissue Specificity

Expressed in blood and bone marrow.

Target Research Area

Signal Transduction

Target Synonyms

AHSP; AHSP_HUMAN; Alpha hemoglobin stabilizing protein; Alpha-hemoglobin-stabilizing protein; EDRF; ERAF; Erythroid associated factor; Erythroid differentiation associated factor; Erythroid differentiation related factor; Erythroid differentiation-related factor; Erythroid-associated factor

Target Background

This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants.