Recombinant Human Alpha-protein kinase 1 (ALPK1), Truncated

Uniprot Id

Q96QP1

Target Species

Human

Target Name

ALPK1

Target Full Name

Alpha-protein kinase 1

Target Function

Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A. May play a role in ciliogenesis.

Target Subcellular Location

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.

Target Protein Families

Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily

Target Tissue Specificity

Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina.

Target Synonyms

8430410J10Rik; Alpha protein kinase 1; Alpha-protein kinase 1; ALPK1; ALPK1_HUMAN; Chromosome 4 kinase; LAK; Lymphocyte alpha kinase; Lymphocyte alpha protein kinase; Lymphocyte alpha-protein kinase; RGD1304613

Target Background

This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene.