Recombinant Human Amine oxidase [flavin-containing] A (MAOA), Truncated

Uniprot Id

P21397

Target Species

Human

Target Name

MAOA

Target Full Name

Amine oxidase [flavin-containing] A

Target Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Target Involvement

Brunner syndrome (BRNRS)

Target Subcellular Location

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Target Protein Families

Flavin monoamine oxidase family

Target Tissue Specificity

Heart, liver, duodenum, blood vessels and kidney.

Target Synonyms

MAOA; Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A

Target Background

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.