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Amino acids 2-489 form the expressed segment for recombinant Human MAOB. This MAOB protein is theoretically predicted to have a molecular weight of 59.3 kDa. This protein is generated in a e.coli-based system. The MAOB gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant MAOB protein during the following stages.Human amine oxidase [flavin-containing] B (MAOB) plays a crucial role in the catabolism of biogenic amines, including neurotransmitters like dopamine, serotonin, and norepinephrine. Located in the outer mitochondrial membrane, MAOB catalyzes the oxidative deamination of these amines, contributing to the regulation of neurotransmitter levels. Its involvement in the breakdown of dopamine makes MAOB a target in neurological disorders such as Parkinson's disease. Beyond its role in neurobiology, MAOB is involved in cardiovascular health and age-related conditions. The exploration of MAOB extends across various research areas, including neuroscience, cardiology, and gerontology, emphasizing its significance in understanding and potentially treating diverse medical conditions.
Amino acids 2-489 form the expressed segment for recombinant Human MAOB. This MAOB protein is theoretically predicted to have a molecular weight of 59.3 kDa. This protein is generated in a e.coli-based system. The MAOB gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant MAOB protein during the following stages.Human amine oxidase [flavin-containing] B (MAOB) plays a crucial role in the catabolism of biogenic amines, including neurotransmitters like dopamine, serotonin, and norepinephrine. Located in the outer mitochondrial membrane, MAOB catalyzes the oxidative deamination of these amines, contributing to the regulation of neurotransmitter levels. Its involvement in the breakdown of dopamine makes MAOB a target in neurological disorders such as Parkinson’s disease. Beyond its role in neurobiology, MAOB is involved in cardiovascular health and age-related conditions. The exploration of MAOB extends across various research areas, including neuroscience, cardiology, and gerontology, emphasizing its significance in understanding and potentially treating diverse medical conditions.
| Cat.No | ACP04786 | Target Name | MAOB |
|---|---|---|---|
| Target Synonyms | Adrenalin oxidase; Amine oxidase (flavin containing); Amine oxidase [flavin-containing] B; AOFB_HUMAN; MAO, brain; MAO, platelet; MAO-B; MAOB; MGC26382; Monoamine oxidase B; Monoamine oxidase type B; OTTHUMP00000023166; Tyramine oxidase | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 2-489aa |
| Mol Weight | 59.3kDa | Protein Length | Cytoplasmic Domain |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P27338 |
|---|
Uniprot Id
P27338
Target Species
Human
Target Name
MAOB
Target Full Name
Amine oxidase [flavin-containing] B
Target Function
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Target Subcellular Location
Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Target Protein Families
Flavin monoamine oxidase family
Target Research Area
Neuroscience
Target Synonyms
Adrenalin oxidase; Amine oxidase (flavin containing); Amine oxidase [flavin-containing] B; AOFB_HUMAN; MAO, brain; MAO, platelet; MAO-B; MAOB; MGC26382; Monoamine oxidase B; Monoamine oxidase type B; OTTHUMP00000023166; Tyramine oxidase
Target Background
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine.
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