Recombinant Human Anaphase-promoting complex subunit 13 (ANAPC13)

Uniprot Id

Q9BS18

Target Species

Human

Target Name

ANAPC13

Target Full Name

Anaphase-promoting complex subunit 13

Target Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Target Subcellular Location

Nucleus.

Target Protein Families

APC13 family

Target Synonyms

ANAPC13; Anaphase-promoting complex subunit 13; APC13; APC13_HUMAN; Cyclosome subunit 13; DKFZP566D193; SWM1

Target Background

This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined.