Recombinant Human Anaphase-promoting complex subunit 7 (ANAPC7)

Uniprot Id

Q9UJX3

Target Species

Human

Target Name

ANAPC7

Target Full Name

Anaphase-promoting complex subunit 7

Target Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Target Subcellular Location

Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.

Target Protein Families

APC7 family

Target Synonyms

anapc7; Anaphase promoting complex subunit 7; Anaphase-promoting complex subunit 7; APC 7; APC7; APC7_HUMAN; Cyclosome subunit 7; Prediabetic NOD sera reactive autoantigen

Target Background

This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene.