Recombinant Human Ankyrin repeat domain-containing protein 1 (ANKRD1)

Uniprot Id

Q15327

Target Species

Human

Target Name

ANKRD1

Target Full Name

Ankyrin repeat domain-containing protein 1

Target Function

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.

Target Involvement

Total anomalous pulmonary venous return (TAPVR)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.

Target Synonyms

ALRP; ANKR1_HUMAN; ANKRD 1; ANKRD1; Ankyrin repeat domain 1 (cardiac muscle); Ankyrin repeat domain containing protein 1 ; Ankyrin repeat domain-containing protein 1; bA320F15.2 ; C 193; C193; Cardiac ankyrin repeat protein; CARP; CVARP; Cytokine inducible nuclear protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein; HA1A2; Liver ankyrin repeat domain 1 ; MCARP; OTTHUMP00000020084

Target Background

The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.