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Amino acids 2-319 constitute the expression domain of recombinant Human ANXA4. This ANXA4 protein is theoretically predicted to have a molecular weight of 55.8 kDa. This ANXA4 recombinant protein is manufactured in e.coli. The N-terminal 10xHis-SUMO tag and C-terminal Myc tag was fused into the coding gene segment of ANXA4, making it easier to detect and purify the ANXA4 recombinant protein in the later stages of expression and purification.Annexin A4 (ANXA4) is a protein that has recently attracted a lot of attention in research, especially in the study of cancer. It plays a crucial role in tumor invasion and metastasis. Researchers have found that when ANXA4 is excessively expressed, it is closely linked to the development and worsening of certain cancers, such as breast cancer and lung cancer. This makes ANXA4 a potential marker for cancer and a target for treatment, offering new perspectives for detecting and treating cancer early. Additionally, ANXA4 is connected to the regulation of inflammation and the immune system. Studies show its involvement in controlling cell apoptosis, inflammatory responses, and immune regulation, providing important insights into understanding diseases related to the immune system and inflammation.
Amino acids 2-319 constitute the expression domain of recombinant Human ANXA4. This ANXA4 protein is theoretically predicted to have a molecular weight of 55.8 kDa. This ANXA4 recombinant protein is manufactured in e.coli. The N-terminal 10xHis-SUMO tag and C-terminal Myc tag was fused into the coding gene segment of ANXA4, making it easier to detect and purify the ANXA4 recombinant protein in the later stages of expression and purification.Annexin A4 (ANXA4) is a protein that has recently attracted a lot of attention in research, especially in the study of cancer. It plays a crucial role in tumor invasion and metastasis. Researchers have found that when ANXA4 is excessively expressed, it is closely linked to the development and worsening of certain cancers, such as breast cancer and lung cancer. This makes ANXA4 a potential marker for cancer and a target for treatment, offering new perspectives for detecting and treating cancer early. Additionally, ANXA4 is connected to the regulation of inflammation and the immune system. Studies show its involvement in controlling cell apoptosis, inflammatory responses, and immune regulation, providing important insights into understanding diseases related to the immune system and inflammation.
| Cat.No | ACP02422 | Target Name | ANXA4 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-319aa | Mol Weight | 55.8 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P09525 |
|---|
Uniprot Id
P09525
Target Species
Human
Target Name
ANXA4
Target Full Name
Annexin A4
Target Function
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
Target Subcellular Location
Zymogen granule membrane; Peripheral membrane protein.
Target Protein Families
Annexin family
Target Research Area
Cardiovascular
Target Synonyms
35 beta calcimedin; 35-beta calcimedin; AIV; Annexin 4; Annexin A4; Annexin IV (placental anticoagulant protein II); Annexin IV; Annexin IV placental anticoagulant protein II; Annexin-4; AnnexinA4; AnnexinIV; ANX 4; ANX A4; ANX4; ANXA 4; ANXA4; ANXA4 protein; ANXA4_HUMAN; Carbohydrate binding protein P33/P41; Carbohydrate-binding protein p33/p41; Chromobindin 4; Chromobindin-4; Chromobindin4; DKFZp686H02120; Endonexin I; EndonexinI; Lipocortin IV; LipocortinIV; MGC75105; OTTHUMP00000160052; OTTHUMP00000202207; P32.5; P33/41; PAP II; PAP-II; PAPII; PIG 28; PIG28; Placental anticoagulant protein II; PP4 X; PP4-X; PP4X; Proliferation inducing gene 28; Proliferation inducing protein 28; Protein II; Xanx-4; ZAP 36; ZAP36
Target Background
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene.
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