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The recombinant Human ANXA5 was expressed with the amino acid range of 2-320. The theoretical molecular weight of the ANXA5 protein is 37.8 kDa. This protein is generated in a yeast-based system. The ANXA5 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant ANXA5 protein during the following stages.The human Annexin A5 (ANXA5) is a cellular protein belonging to the annexin family, known for its calcium-dependent phospholipid-binding properties. ANXA5 plays a role in several cellular processes, including membrane trafficking, vesicle formation, and apoptosis regulation. ANXA5 has a unique ability to bind to phospholipids in a calcium-dependent manner, which can influence membrane structure and function. Additionally, ANXA5 has anti-coagulant properties and is used in clinical settings as a marker for apoptosis due to its ability to bind to phosphatidylserine exposed on the outer leaflet of apoptotic cell membranes. Research on ANXA5 extends to its involvement in various physiological and pathological processes, including blood clotting, immune response, and cancer.
The recombinant Human ANXA5 was expressed with the amino acid range of 2-320. The theoretical molecular weight of the ANXA5 protein is 37.8 kDa. This protein is generated in a yeast-based system. The ANXA5 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant ANXA5 protein during the following stages.The human Annexin A5 (ANXA5) is a cellular protein belonging to the annexin family, known for its calcium-dependent phospholipid-binding properties. ANXA5 plays a role in several cellular processes, including membrane trafficking, vesicle formation, and apoptosis regulation. ANXA5 has a unique ability to bind to phospholipids in a calcium-dependent manner, which can influence membrane structure and function. Additionally, ANXA5 has anti-coagulant properties and is used in clinical settings as a marker for apoptosis due to its ability to bind to phosphatidylserine exposed on the outer leaflet of apoptotic cell membranes. Research on ANXA5 extends to its involvement in various physiological and pathological processes, including blood clotting, immune response, and cancer.
| Cat.No | ACP02563 | Target Name | ANXA5 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Yeast |
| Expression Range | 2-320aa | Mol Weight | 37.8kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P08758 |
|---|
Uniprot Id
P08758
Target Species
Human
Target Name
ANXA5
Target Full Name
Annexin A5
Target Function
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Target Involvement
Pregnancy loss, recurrent, 3 (RPRGL3)
Target Protein Families
Annexin family
Target Research Area
Cancer, Cardiovascular
Target Synonyms
Anchorin CII; Annexin 5; Annexin A5; Annexin V; Annexin-5; Annexin5; AnnexinA5; AnnexinV; ANX 5; ANX A5; ANX5; ANXA5; ANXA5_HUMAN; Calphobindin I; CBP-I; Endonexin II; ENX 2; ENX2; Lipocortin V; PAP I; PAP-I; Placental anticoagulant protein 4; Placental anticoagulant protein I; PLACENTAL PROTEIN 4; PP 4; Pp4; RPRGL3; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha
Target Background
The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications.
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