Recombinant Human Anoctamin-6 (ANO6), Truncated

Cat.No	ACP06151	Target Name	ANO6
Target Synonyms	2900059G15Rik; AA407480; Ano6; ANO6_HUMAN; Anoctamin 6; Anoctamin-6; AW554778; BDPLT7; F730003B03Rik; MGC104751; SCTS; TMEM16F; Transmembrane protein 16F	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP06151

Target Name

ANO6

Target Synonyms

2900059G15Rik; AA407480; Ano6; ANO6_HUMAN; Anoctamin 6; Anoctamin-6; AW554778; BDPLT7; F730003B03Rik; MGC104751; SCTS; TMEM16F; Transmembrane protein 16F

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q4KMQ2

Background Information

Uniprot Id

Q4KMQ2
Target Species

Human
Target Name

ANO6
Target Full Name

Anoctamin-6
Target Function

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.; Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.
Target Involvement

Scott syndrome (SCTS)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to PubMed:22075693.
Target Protein Families

Anoctamin family
Target Tissue Specificity

Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.
Target Synonyms

2900059G15Rik; AA407480; Ano6; ANO6_HUMAN; Anoctamin 6; Anoctamin-6; AW554778; BDPLT7; F730003B03Rik; MGC104751; SCTS; TMEM16F; Transmembrane protein 16F
Target Background

This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Anoctamin-6 (ANO6), Truncated

Specifications

Immunogen Information

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