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In baculovirus cells, the generation of the recombinant Human SERPINC1 protein includes integrating a DNA fragment encoding the Human SERPINC1 protein (1-464aa) into a plasmid vector and transforming this vector into baculovirus cells. Cells containing the plasmid are screened, cultured, and induced to yield the SERPINC1 protein. A N-terminal 6xHis tag is attached to the protein. Lysis of the cells facilitates the collection of the recombinant Human SERPINC1 protein, which is subjected to affinity purification and then SDS-PAGE analysis and subsequent staining of the gel with Coomassie Brilliant Blue. The purity of the obtained recombinant Human SERPINC1 protein is greater than 85%.
In baculovirus cells, the generation of the recombinant Human SERPINC1 protein includes integrating a DNA fragment encoding the Human SERPINC1 protein (1-464aa) into a plasmid vector and transforming this vector into baculovirus cells. Cells containing the plasmid are screened, cultured, and induced to yield the SERPINC1 protein. A N-terminal 6xHis tag is attached to the protein. Lysis of the cells facilitates the collection of the recombinant Human SERPINC1 protein, which is subjected to affinity purification and then SDS-PAGE analysis and subsequent staining of the gel with Coomassie Brilliant Blue. The purity of the obtained recombinant Human SERPINC1 protein is greater than 85%.
| Cat.No | ACP01833 | Target Name | SERPINC1 |
|---|---|---|---|
| Target Synonyms | Serpin C1 | Form | Liquid or Lyophilized powder |
| Expression System | Baculovirus | Expression Range | 1-464aa |
| Mol Weight | 53.6 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P01008 |
|---|
Uniprot Id
P01008
Target Species
Human
Target Name
SERPINC1
Target Full Name
Antithrombin-III
Target Function
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Target Involvement
Antithrombin III deficiency (AT3D)
Target Subcellular Location
Secreted, extracellular space.
Target Protein Families
Serpin family
Target Tissue Specificity
Found in plasma.
Target Research Area
Cardiovascular
Target Synonyms
Serpin C1
Target Background
The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19).
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