Recombinant Human AP-4 complex subunit sigma-1 (AP4S1)

Uniprot Id

Q9Y587

Target Species

Human

Target Name

AP4S1

Target Full Name

AP-4 complex subunit sigma-1

Target Function

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal

Target Involvement

Spastic paraplegia 52, autosomal recessive (SPG52)

Target Subcellular Location

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.

Target Protein Families

Adaptor complexes small subunit family

Target Tissue Specificity

Widely expressed.

Target Synonyms

AP4S1AP-4 complex subunit sigma-1; AP-4 adaptor complex subunit sigma-1; Adaptor-related protein complex 4 subunit sigma-1; Sigma-1 subunit of AP-4; Sigma-4-adaptin; Sigma4-adaptin