Recombinant Human APC membrane recruitment protein 1 (FAM123B), Truncated

Uniprot Id

Q5JTC6

Target Species

Human

Target Name

AMER1

Target Full Name

APC membrane recruitment protein 1

Target Function

Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.

Target Involvement

Osteopathia striata with cranial sclerosis (OSCS)

Target Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2.

Target Protein Families

Amer family

Target Tissue Specificity

Detected in fetal and adult kidney, brain and spleen.

Target Synonyms

AMER1; FAM123B; WTXAPC membrane recruitment protein 1; Amer1; Protein FAM123B; Wilms tumor gene on the X chromosome protein