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Amino acids 21-396 constitute the expression domain of recombinant Human APOA4. The expected molecular weight for the APOA4 protein is calculated to be 59.4 kDa. The APOA4 protein was expressed in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of APOA4, making it easier to detect and purify the APOA4 recombinant protein in the later stages of expression and purification.Apolipoprotein A-IV (APOA4) is a protein that has attracted a lot of interest in various research areas lately. In the study of lipid metabolism, researchers are mainly looking at how APOA4 impacts cholesterol and triglyceride levels. Studies show that APOA4 plays a vital role in transporting and absorbing cholesterol, crucial for maintaining a healthy balance of lipids in the body. What's especially interesting is the attention it's getting in research on metabolic and heart diseases. Its connection to issues like lipid disorders and atherosclerosis suggests it could be a useful marker and target for treatments.
Amino acids 21-396 constitute the expression domain of recombinant Human APOA4. The expected molecular weight for the APOA4 protein is calculated to be 59.4 kDa. The APOA4 protein was expressed in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of APOA4, making it easier to detect and purify the APOA4 recombinant protein in the later stages of expression and purification.Apolipoprotein A-IV (APOA4) is a protein that has attracted a lot of interest in various research areas lately. In the study of lipid metabolism, researchers are mainly looking at how APOA4 impacts cholesterol and triglyceride levels. Studies show that APOA4 plays a vital role in transporting and absorbing cholesterol, crucial for maintaining a healthy balance of lipids in the body. What’s especially interesting is the attention it’s getting in research on metabolic and heart diseases. Its connection to issues like lipid disorders and atherosclerosis suggests it could be a useful marker and target for treatments.
| Cat.No | ACP04402 | Target Name | APOA4 |
|---|---|---|---|
| Target Synonyms | APOA4Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 21-396aa |
| Mol Weight | 59.4kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P06727 |
|---|
Uniprot Id
P06727
Target Species
Human
Target Name
APOA4
Target Full Name
Apolipoprotein A-IV
Target Function
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Target Subcellular Location
Secreted.
Target Protein Families
Apolipoprotein A1/A4/E family
Target Tissue Specificity
Synthesized primarily in the intestine and secreted in plasma.
Target Research Area
Cancer, Cardiovascular
Target Synonyms
APOA4Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4
Target Background
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.
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