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Recombinant Human Apolipoprotein A-IV (APOA4)

ACP04656

Number
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Specifications


Cat.No ACP04656 Target NameAPOA4
Target SynonymsAPOA4Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4FormLiquid or Lyophilized powder
Expression SystemYeastExpression Range21-396aa
Mol Weight45.4 kDaProtein LengthFull Length of Mature Protein
PurityGreater than 85% as determined by SDS-PAGE.Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDP06727
Background Information
  • Uniprot Id

    P06727

  • Target Species

    Human

  • Target Name

    APOA4

  • Target Full Name

    Apolipoprotein A-IV

  • Target Function

    May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

  • Target Subcellular Location

    Secreted.

  • Target Protein Families

    Apolipoprotein A1/A4/E family

  • Target Tissue Specificity

    Synthesized primarily in the intestine and secreted in plasma.

  • Target Research Area

    Cancer, Cardiovascular

  • Target Synonyms

    APOA4Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4

  • Target Background

    Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.

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