Recombinant Human Apolipoprotein L3 (APOL3)

Uniprot Id

O95236

Target Species

Human

Target Name

APOL3

Target Full Name

Apolipoprotein L3

Target Function

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Apolipoprotein L family

Target Tissue Specificity

Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and

Target Synonyms

ApoL III; ApoL-III; APOL3; APOL3_HUMAN; APOLIII; Apolipoprotein L 3; Apolipoprotein L III; Apolipoprotein L-III; Apolipoprotein L3; Apolipoprotein LIII; CG12 1; CG12_1; CG121; TNF inducible protein CG12 1; TNF-inducible protein CG12-1

Target Background

This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants.