Recombinant Human Apolipoprotein M (APOM)

Amino acids 1-188 constitute the expression domain of recombinant Human APOM. The expected molecular weight for the APOM protein is calculated to be 49.8 kDa. This protein is generated in a e.coli-based system. The N-terminal 10xHis-GST tag was fused into the coding gene segment of APOM, making it easier to detect and purify the APOM recombinant protein in the later stages of expression and purification.Apolipoprotein M (APOM) is a protein involved in lipid metabolism, with research spanning various fields. One of the most noteworthy areas is its role in cholesterol transport and metabolism. As part of high-density lipoprotein (HDL), APOM contributes to regulating the transport and metabolism of cholesterol, playing a crucial role in maintaining lipid balance. Some studies indicate that APOM is also involved in immune regulation and inflammatory processes. Its interaction with the immune system, particularly in the regulatory mechanisms of antimicrobial immunity, has become a forefront of research. Besides, APOM is associated with some chronic diseases such as diabetes and atherosclerosis, exerting a regulatory role in the pathogenesis of these conditions.