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Recombinant Human Apoptosis inhibitor 5 (API5)

ACP19004

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP19004 Target NameAPI5
FormLyophilized powderExpression SystemCustom Production. Please inquire and provide the desire expression system.
Expression Range2-524Protein LengthFull Length of Mature Protein
Purity>85% (SDS-PAGE)Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ9BZZ5
Background Information
  • Uniprot Id

    Q9BZZ5

  • Target Species

    Human

  • Target Name

    API5

  • Target Full Name

    Apoptosis inhibitor 5

  • Target Function

    Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

  • Target Subcellular Location

    Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic.; [Isoform 3]: Cytoplasm.

  • Target Protein Families

    API5 family

  • Target Tissue Specificity

    Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma

  • Target Synonyms

    AAC 11; AAC-11; AAC11; Antiapoptosis clone 11 protein; API 5; API-5; api5; API5 like 1; API5_HUMAN; API5L1; Apoptosis inhibitor 5; Cell migration inducing gene 8 protein; Cell migration-inducing gene 8 protein; Fibroblast growth factor 2 interacting factor 2; Fibroblast growth factor 2-interacting factor; FIF; MIG 8; MIG8; Migration inducing protein MIG8; Protein XAGL

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