Recombinant Human Arachidonate 12-lipoxygenase, 12R-type (ALOX12B)

Uniprot Id

O75342

Target Species

Human

Target Name

ALOX12B

Target Full Name

Arachidonate 12-lipoxygenase, 12R-type

Target Function

Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.

Target Involvement

Ichthyosis, congenital, autosomal recessive 2 (ARCI2)

Target Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region.

Target Protein Families

Lipoxygenase family

Target Tissue Specificity

Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue.

Target Synonyms

ALOX12B; Arachidonate 12-lipoxygenase; 12R-type; 12R-LOX; 12R-lipoxygenase; EC 1.13.11.-; Epidermis-type lipoxygenase 12

Target Background

This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.