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| Cat.No | ACP24055 | Target Name | DDC |
|---|---|---|---|
| Target Synonyms | AADC; Aromatic L Amino Acid Decarboxylase; Aromatic-L-amino-acid decarboxylase; DDC; DDC_HUMAN; DOPA decarboxylase (aromatic L-amino acid decarboxylase); DOPA decarboxylase | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-480 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P20711 |
|---|
Uniprot Id
P20711
Target Species
Human
Target Name
DDC
Target Full Name
Aromatic-L-amino-acid decarboxylase
Target Function
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Target Involvement
Aromatic L-amino-acid decarboxylase deficiency (AADCD)
Target Protein Families
Group II decarboxylase family
Target Synonyms
AADC; Aromatic L Amino Acid Decarboxylase; Aromatic-L-amino-acid decarboxylase; DDC; DDC_HUMAN; DOPA decarboxylase (aromatic L-amino acid decarboxylase); DOPA decarboxylase
Target Background
The encoded protein catalyzes the decarboxylation of L-3, 4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
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