Recombinant Human Arylacetamide deacetylase (AADAC), Truncated

Uniprot Id

P22760

Target Species

Human

Target Name

AADAC

Target Full Name

Arylacetamide deacetylase

Target Function

Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.

Target Protein Families

'GDXG' lipolytic enzyme family

Target Tissue Specificity

Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.

Target Research Area

Signal Transduction

Target Synonyms

AAAD_HUMAN; Aada; Aadac; Arylacetamide deacetylase (esterase); Arylacetamide deacetylase; CES5A1; DAC

Target Background

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens