Recombinant Human Arylsulfatase B (ARSB)

Uniprot Id

P15848

Target Species

Human

Target Name

ARSB

Target Full Name

Arylsulfatase B

Target Function

Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels.

Target Involvement

Mucopolysaccharidosis 6 (MPS6); Multiple sulfatase deficiency (MSD)

Target Subcellular Location

Lysosome. Cell surface.

Target Protein Families

Sulfatase family

Target Research Area

Cancer

Target Synonyms

Arsb; ARSB_HUMAN; Arylsulfatase B; ArylsulfataseB; ASB; G4S; MPS6; N acetylgalactosamine 4 sulfatase; N-acetylgalactosamine-4-sulfatase

Target Background

Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.