Recombinant Human Arylsulfatase G (ARSG)

Uniprot Id

Q96EG1

Target Species

Human

Target Name

ARSG

Target Full Name

Arylsulfatase G

Target Function

Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.

Target Subcellular Location

Lysosome.

Target Protein Families

Sulfatase family

Target Tissue Specificity

Widely expressed, with very low expression in brain, lung, heart and skeletal muscle.

Target Research Area

Tags & Cell Markers

Target Synonyms

Arsg; ARSG_HUMAN; Arylsulfatase G; Arylsulfatase G precursor ; ASG; KIAA1001; PRO1777; UNQ839

Target Background

The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene.