Recombinant Human Astacin-like metalloendopeptidase (ASTL)

Uniprot Id

Q6HA08

Target Species

Human

Target Name

ASTL

Target Full Name

Astacin-like metalloendopeptidase

Target Function

Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.

Target Subcellular Location

Cytoplasm. Cell membrane. Cytoplasmic vesicle, secretory vesicle, Cortical granule.

Target Protein Families

Peptidase M12A family

Target Tissue Specificity

Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas. Not detected in normal tissues.

Target Research Area

Signal Transduction

Target Synonyms

ASTLAstacin-like metalloendopeptidase; EC 3.4.-.-; Oocyte astacin; Ovastacin

Target Background

Predicted to enable aspartic-type peptidase activity; glutamic-type peptidase activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Predicted to be located in cortical granule and plasma membrane.