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| Cat.No | ACP24466 | Target Name | ATXN1L |
|---|---|---|---|
| Target Synonyms | ATXN1L; BOAT; BOAT1Ataxin-1-like; Brother of ataxin-1; Brother of ATXN1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-689 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P0C7T5 |
|---|
Uniprot Id
P0C7T5
Target Species
Human
Target Name
ATXN1L
Target Full Name
Ataxin-1-like
Target Function
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development.
Target Subcellular Location
Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
Target Protein Families
ATXN1 family
Target Tissue Specificity
Expressed in cerebellum and cerebral cortex.
Target Synonyms
ATXN1L; BOAT; BOAT1Ataxin-1-like; Brother of ataxin-1; Brother of ATXN1
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