Recombinant Human ATP-binding cassette sub-family F member 1 (ABCF1), Truncated

Uniprot Id

Q8NE71

Target Species

Human

Target Name

ABCF1

Target Full Name

ATP-binding cassette sub-family F member 1

Target Function

Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.

Target Subcellular Location

[Isoform 2]: Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope.

Target Protein Families

ABC transporter superfamily, ABCF family, EF3 subfamily

Target Tissue Specificity

Ubiquitous.

Target Synonyms

ABC27; ABC50; ABCF1; ABCF1_HUMAN; ATP binding cassette 50 (TNF alpha stimulated); ATP binding cassette 50; ATP binding cassette sub family F member 1; ATP binding cassette; sub family F (GCN20); member 1; ATP-binding cassette 50; ATP-binding cassette sub-family F member 1; AU041969; D17Wsu166e; EST123147; GCN20; TNF alpha stimulated ABC protein; TNF-alpha-stimulated ABC protein; TNFalpha inducible ATP binding protein; wu:fb79c06; wu:fc39a05; wu:fj94a08; zgc:85667

Target Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process.