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In the production of the recombinant Human ATP5F1C protein in e.coli cells, a sequential pipeline involves constructing the expression vector coding for the Human ATP5F1C protein (26-298aa), transforming the recombinant vector into e.coli cells, selecting the positive cells and cultivating them, lysing cells, and characterizing the protein. The resulting recombinant Human ATP5F1C protein is purified from the cell lysate using affinity purification. Its purity exceeds 85%, as determined by SDS-PAGE.
In the production of the recombinant Human ATP5F1C protein in e.coli cells, a sequential pipeline involves constructing the expression vector coding for the Human ATP5F1C protein (26-298aa), transforming the recombinant vector into e.coli cells, selecting the positive cells and cultivating them, lysing cells, and characterizing the protein. The resulting recombinant Human ATP5F1C protein is purified from the cell lysate using affinity purification. Its purity exceeds 85%, as determined by SDS-PAGE.
| Cat.No | ACP02070 | Target Name | ATP5F1C |
|---|---|---|---|
| Target Synonyms | ATP synthase F1 subunit gamma (F-ATPase gamma subunit) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 26-298aa |
| Mol Weight | 37.6 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P36542 |
|---|
Uniprot Id
P36542
Target Species
Human
Target Name
ATP5F1C
Target Full Name
ATP synthase subunit gamma, mitochondrial
Target Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Target Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Target Protein Families
ATPase gamma chain family
Target Tissue Specificity
Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta
Target Research Area
Metabolism
Target Synonyms
ATP synthase gamma chain; mitochondrial; ATP synthase subunit gamma; ATP synthase subunit gamma; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; gamma polypeptide 1; ATP synthase; H+ transporting; mitochondrial F1 complex; gamma subunit; ATP5C 1; ATP5C; ATP5C1; ATP5CL1; ATPG_HUMAN; F ATPase gamma subunit; F-ATPase gamma subunit; mitochondrial; Mitochondrial ATP synthase; gamma subunit 1
Target Background
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.
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