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| Cat.No | ACP13284 | Target Name | ATRIP |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 2-791 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8WXE1 |
|---|
Uniprot Id
Q8WXE1
Target Species
Human
Target Name
ATRIP
Target Full Name
ATR-interacting protein
Target Function
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
Target Subcellular Location
Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage.
Target Protein Families
ATRIP family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
AGS1; ATIP; ATM and Rad3 related interacting protein; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; Atrip; ATRIP_HUMAN; DKFZp762J2115; FLJ12343; MGC20625; MGC21482; MGC26740
Target Background
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
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