Recombinant Human Autism susceptibility gene 2 protein (AUTS2), Truncated

Uniprot Id

Q8WXX7

Target Species

Human

Target Name

AUTS2

Target Full Name

Autism susceptibility gene 2 protein

Target Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation. In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1

Target Involvement

Mental retardation, autosomal dominant 26 (MRD26)

Target Subcellular Location

Nucleus. Cytoplasm, cytoskeleton. Cell projection, growth cone.

Target Protein Families

AUTS2 family

Target Tissue Specificity

Strongly expressed in brain, skeletal muscle and kidney. Also expressed in placenta, lung and leukocytes.

Target Synonyms

Autism related protein 1; Autism susceptibility candidate 2; Autism susceptibility gene 2 protein; AUTS2; AUTS2_HUMAN; FBRSL2; KIAA0442; MGC13140