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The expression region of this recombinant Human NAIP covers amino acids 60-345. This NAIP protein is theoretically predicted to have a molecular weight of 48.6 kDa. Expression of this NAIP protein is conducted in e.coli. Fusion of the N-terminal 6xHis-SUMO tag into the NAIP encoding gene fragment was conducted, allowing for easier detection and purification of the NAIP protein in subsequent stages.Human baculoviral IAP repeat-containing protein 1 (NAIP) is crucial for innate immunity, acting as a sensor for intracellular pathogens. NAIP, part of the NLRC4 inflammasome, recognizes bacterial flagellin and type III secretion systems, triggering inflammatory responses and antimicrobial defenses. In infectious disease research, studying NAIP provides insights into host-pathogen interactions. Its association with autoinflammatory diseases links NAIP to autoimmune research. Moreover, understanding NAIP contributes to the broader field of inflammasome biology, offering potential therapeutic targets for immune-related disorders. Investigating NAIP's diverse functions provides a comprehensive understanding of its roles in immunity and various pathophysiological conditions.
The expression region of this recombinant Human NAIP covers amino acids 60-345. This NAIP protein is theoretically predicted to have a molecular weight of 48.6 kDa. Expression of this NAIP protein is conducted in e.coli. Fusion of the N-terminal 6xHis-SUMO tag into the NAIP encoding gene fragment was conducted, allowing for easier detection and purification of the NAIP protein in subsequent stages.Human baculoviral IAP repeat-containing protein 1 (NAIP) is crucial for innate immunity, acting as a sensor for intracellular pathogens. NAIP, part of the NLRC4 inflammasome, recognizes bacterial flagellin and type III secretion systems, triggering inflammatory responses and antimicrobial defenses. In infectious disease research, studying NAIP provides insights into host-pathogen interactions. Its association with autoinflammatory diseases links NAIP to autoimmune research. Moreover, understanding NAIP contributes to the broader field of inflammasome biology, offering potential therapeutic targets for immune-related disorders. Investigating NAIP’s diverse functions provides a comprehensive understanding of its roles in immunity and various pathophysiological conditions.
| Cat.No | ACP03696 | Target Name | NAIP |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 60-345aa | Mol Weight | 48.6kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13075 |
|---|
Uniprot Id
Q13075
Target Species
Human
Target Name
NAIP
Target Full Name
Baculoviral IAP repeat-containing protein 1
Target Function
Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.; Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.
Target Tissue Specificity
Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.
Target Research Area
Cancer
Target Synonyms
Baculoviral IAP repeat containing 1; Baculoviral IAP repeat-containing protein 1; BIRC 1; BIRC1; BIRC1_HUMAN; Birc1a; FLJ42520; NAIP; Naip1; Neuronal apoptosis inhibitory protein; NLR family apoptosis inhibitory protein; NLR family BIR domain containing 1; NLRB 1; NLRB1; Nucleotide binding oligomerization domain leucine rich repeat and BIR domain containing 1; Psi neuronal apoptosis inhibitory protein; psiNAIP; Similar to occludin
Target Background
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
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