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| Cat.No | ACP11756 | Target Name | BIRC6 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NR09 |
|---|
Uniprot Id
Q9NR09
Target Species
Human
Target Name
BIRC6
Target Full Name
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
Target Function
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.
Target Subcellular Location
Golgi apparatus, trans-Golgi network membrane. Endosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring.
Target Protein Families
Ubiquitin-conjugating enzyme family
Target Tissue Specificity
Expressed in brain cancer cells.
Target Synonyms
Apollon; Apollon protein; Baculoviral IAP repeat containing 6; Baculoviral IAP repeat containing protein 6; Baculoviral IAP repeat-containing protein 6; BIR repeat containing ubiquitin conjugating enzyme; BIRC 6; BIRC6; BIRC6_HUMAN; BRUCE; FLJ13726; FLJ13786; KIAA1289; Ubiquitin conjugating BIR domain enzyme apollon; Ubiquitin-conjugating BIR domain enzyme apollon
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